Mitochondria‐Targeted Bovine Serum Albumin@Copper Sulfide Nanocomposites Conjugated with Rhodamine‐110 Dye for an Enhanced Efficacy of Cancer Photothermal Therapy

Recently, mitochondria-targeted photothermal nanoagents demonstrated an improved therapeutic efficacy of cancer cells, compared with non-targeting ones. Herein, copper sulfide (CuS) nanoparticles are in situ synthesized via bovine serum albumin (BSA) templates to prepare BSA@CuS nanocomposites high efficiency (42.0%) conversion. Subsequently, rhodamine-110 (R) molecules covalently conjugated construct R-BSA@CuS nanocomposites, which still retained 22.8% conversion efficiency. Furthermore, as-prepared can be efficiently internalized by human breast (MCF-7) and then specifically accumulated their subcellular mitochondria, not lysosomes. Compared these show a significant enhancement (***p < 0.001) anticancer under the same near-infrared irradiation conditions, whose mechanism is further explored details. Finally, succeed penetrating 3D multicellular tumor spheroids composed MCF-7 cells. And they also inhibition effect (**p 0.01) on growth therapy, contrast bare conditions. Therefore, have important potential applications therapy enhanced efficacy.